Penis Botox Benefits, Procedure and Cost in 2026: What the Evidence Says

Penis Botox (male penis Botox, or “Botox en el pene” in Spanish) is an off-label injection of botulinum toxin into the penis, mainly studied for erectile dysfunction (ED) that does not respond to tablets and for penile retraction. Yes, you can get Botox in your penis from a doctor, but the evidence is still limited: small trials show better erections for some men for a few months, there is no proof that it makes the erect penis bigger, and the European urology guideline does not yet recommend it for routine use (Source: EAU Guidelines).

A lot of guys want their erections to be stronger and their penis to be bigger, both in length and width. For many, this is tied to confidence and a sense of masculinity.

Many mens complaints about their penis go beyond its size to include problems with their sexual well-being. Many, for instance, have erectile dysfunction, which may make them feel self-conscious and ashamed of their bodies. ED is very common: providers estimate that it affects more than half of men aged 40 to 70, and it can be the first sign of another health problem such as heart disease (Source: Cleveland Clinic).

Injecting botulinum toxins (BoNT), best known by the brand name Botox, is being researched as a treatment that may help some men with “ED” problems regain their sexual health. It is not an approved treatment: there are no FDA-approved indications for botulinum toxin in male sexual problems, so its use in the penis is off-label, and claims that it can increase the size of the penis are not supported by good evidence (Source: Sexual Medicine Reviews, 2021).

Botox does have approved therapeutic uses in urology, such as overactive bladder and bladder leakage caused by nerve problems, as well as migraine, muscle spasticity and frown lines; ED and penis enlargement are not on that list, so more discussion and more research on its uses in men’s health can be expected in the coming years (Source: MedlinePlus).

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What Is Penis Botox?

Penis Botox is a doctor-given injection of botulinum toxin type A either into the erectile tissue of the penis (the corpora cavernosa), which is how it is studied for erectile dysfunction, or into the thin dartos muscle under the skin of the penis and scrotum, which is how it is studied for penile retraction. Both uses are investigational (Sources: Life systematic review, 2025, Journal of Sexual Medicine, 2009).

Botox Penile Injections

Botox penile injections contain botulinum toxin (BoNT) and are being studied for erectile dysfunction (ED) and for a flaccid penis that pulls in or “retracts”. This is a novel, off-label technique, not an established male enhancement treatment (Source: Sexual Medicine Reviews, 2021).

Since these injections are neurotoxins, they block the release of chemical messengers (acetylcholine and noradrenaline) from nerve endings, so the muscle those nerves control relaxes for weeks to months. In the erectile tissue, this is thought to reduce the nerve signals that keep blood vessels narrowed (Source: Life systematic review, 2025).

To promote more blood flow, the injectable Botox relaxes the treated region: the smooth muscle of the erectile tissue and its vessel walls when the aim is ED, or the dartos muscle of the penis and scrotum when the aim is less retraction.

Therefore, injections of BoNT may improve erection hardness in some men: when the vessel walls are relaxed, more blood can enter the penis. Trials measured better blood flow on penile Doppler ultrasound and better erection scores two weeks after a single injection, but they did not show a larger erect penis (Source: Andrology RCT, 2022).

For medical experts, Botox penile injections are a research option for problems including erectile dysfunction (ED) and penile retraction, and botulinum toxin has also been studied for premature ejaculation, Peyronie’s disease and chronic scrotal pain. These uses are less well known than cosmetic applications, and none of them is FDA-approved (Source: Sexual Medicine Reviews, 2021).

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Benefits of Penis Botox

The possible benefits of penis Botox are firmer erections for some men whose ED did not improve with tablets, and less retraction of the flaccid penis; both are based on small studies, and the effect is temporary. The reasons behind the current interest in injecting Botox in penis among men include the following:

Robust Erection

Problems with blood flow into the penis are the most common cause of ED. This frequently leaves the penis weaker or unable to get an erection and/or keep it, especially during sexual activity (Source: Cleveland Clinic).

In a 2022 placebo-controlled trial of 70 men whose ED did not respond to tablets, 53% of those given a single 100-unit injection could have an erection hard enough for penetration at six weeks, compared with one man in the placebo group (Source: Andrology RCT, 2022).

A second trial of 176 men found that about 40% responded and could have intercourse, with the best effect around the third month; at six months, 100 units lasted better than 50 units (Source: Andrology RCT, 2021).

More Confidence

For men, erectile dysfunction and worries about penis size are distressing because they directly affect self-confidence. Many men associate self-confidence with sexual health and a sense of “manhood”, so better erections can help confidence in a relationship. In a 2026 study of men with penile retraction treated with Botox plus a traction device, self-esteem and genital self-image scores improved, although the study had no comparison group (Source: Int J Impot Res, 2026).

Enhance Penis Size

There is no good evidence that Botox can enlarge, lengthen or thicken the erect penis. What it may change is the “hang” of the flaccid penis in men whose penis retracts. In the first report, 10 men received 100 units into the dartos muscle; 7 felt less retraction, the measured change was mainly less retraction rather than more length, and the effect had gone by six months (Source: Journal of Sexual Medicine, 2009).

A 2026 study of 168 men combined Botox with penile traction and reported a longer flaccid penis at six months (average 4.4 cm to 6.9 cm), with no change in erect length; the authors stress that this is not true anatomical lengthening and that the single-arm design calls for caution (Source: Int J Impot Res, 2026).

Balanced Scrotal Tightness

Men may feel self-conscious if they believe that their scrotum looks unattractive due to scrotal tightness. When the dartos muscle of the scrotum contracts, for example in the cold, the scrotum pulls up and bunches, and some men also feel discomfort. Botox in the scrotum (sometimes called “Scrotox”) is an off-label cosmetic use aimed at relaxing that muscle, and the published evidence for it is small (Source: Annals of Plastic Surgery, 2026).

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How Is Penis Botox Provided?

Penis Botox is given by a doctor as a short in-clinic injection; it is not a self-injection treatment. To make sure the patient is a good fit for the procedure, a urologist or andrologist should first assess the cause of the ED, review medicines and health conditions, and explain that the use is off-label. In the trials, erection hardness and penile blood flow on Doppler ultrasound were measured before treatment (Source: Andrology RCT, 2022).

Medical personnel give a measured dose into a specific part of the penis. In the randomized trials, men received a single injection of 50 or 100 units of botulinum toxin type A into the erectile tissue, and 100 units diluted in 2 ml of saline was the most studied dose (Sources: Andrology RCT, 2022, Andrology RCT, 2021).

A numbing cream or gel may be applied before Botox injections in the penile region, and some doctors use a local anaesthetic injection; the needle is fine and the injection itself takes only a few minutes.

The effects of botulinum toxin for ED and penile retraction are not permanent, just like any neurotoxin therapy. In one trial, the effect peaked around the third month and was still present at six months, more so with 100 units than with 50 units, while one retrospective series reported a longer median effect of about nine months (Sources: Andrology RCT, 2021, Sexual Medicine, 2025).

To keep the effect, patients may be offered repeat injections; in one retrospective series the response rate rose with the second, third and fourth injection, but this has not yet been tested in controlled trials (Source: Sexual Medicine, 2025).

A balanced diet, regular exercise and stopping smoking will not make Botox last longer, but they help erections in their own right and may even reverse some mild cases of ED (Source: Cleveland Clinic).

Botox For Erectile Dysfunction

Botox for erectile dysfunction is an experimental second-line option: it has been tested mainly in men whose ED did not improve with tablets or with standard penile injections. Millions of men in America and Europe have erectile dysfunction or ED. Although Botox has historically been used in cosmetic treatment, it is now also being studied to treat ED (Source: Life systematic review, 2025).

Many clinics use off-label Botox to relax the smooth muscles in the cavernous tissue of the penis. This relaxation causes more blood to enter the spongy region of the penis, making erections easier to obtain.

The treatment temporarily relaxes the smooth muscle in the erectile tissue and in the walls of the blood vessels that supply the penis, which may let more blood flow in during an erection. This is achieved by blocking the nerve signals (from sympathetic, noradrenaline-releasing nerves) that ordinarily keep the vessels constricted (Source: Life systematic review, 2025).

Those who don’t react well to phosphodiesterase-5 inhibitors (Viagra sildenafil or Cialis tadalafil) are the group in which these Botox injections have been tested. Reviews of the studies report response rates between about 40% and 77.5%, better results in mild to moderate ED, mostly mild side effects, and conclude that Botox should still be considered an investigational therapy (Source: Life systematic review, 2025).

A 2025 meta-analysis found only two randomized trials and four retrospective studies, and concluded that more randomized trials are needed before definitive clinical recommendations can be made (Source: Sexual Medicine, 2025).

What Do Urology Guidelines Say About Botox for ED?

The European Association of Urology says the data on botulinum toxin for ED are still limited and that no recommendation for its use in clinical practice can be given at present. The established options it recommends are PDE5 inhibitor tablets first, then penile injections of alprostadil, vacuum erection devices, low-intensity shockwave therapy for selected men, and a penile prosthesis when other treatments fail (Source: EAU Guidelines).

The NHS likewise lists PDE5 medicines, vacuum pumps, treating the underlying cause and lifestyle changes as the main treatments for erection problems, and advises seeing a doctor if they keep happening because they can be a sign of a treatable health condition (Source: NHS).

Botox for Ed Cost

Botox penile injections in Turkey typically cost from about $810, and most published quotes for penis Botox alone in 2026 fall between roughly $1,000 and $2,200. The cost goes up and down depending on the dosage (number of units), the toxin brand, the location, the expertise of the physician, and whether tests, follow-up visits or other treatments are included in the package. Some clinics also announce offers from time to time, so ask for a written quote that lists what is included.

Because penis Botox is off-label and its effect is temporary, the real cost includes possible repeat injections. At International Clinics, the price is confirmed after a urology consultation, once the doctor has assessed whether Botox is a sensible option for you.

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Risks of Penis Botox

Penile injections might result in brief local side effects including pain, bruising or swelling at the injection site, much like other Botox applications. In the studies, the most common side effect was mild, short-lived penile pain in about 1.5% to 6% of men, and no serious body-wide side effects were reported (Source: Life systematic review, 2025).

More serious problems are rare but have been reported: one case of priapism (a prolonged erection) at six months in one trial, prolonged erections during the Doppler test in a few men, and one burn in a retrospective series (Source: Sexual Medicine, 2025).

Botox also carries a general warning that the toxin can spread from the injection site, with symptoms such as weakness, double or blurred vision, drooping eyelids, trouble speaking, swallowing or breathing, which can appear hours to weeks later; trouble breathing or swallowing needs emergency care (Source: MedlinePlus).

An erection that lasts more than 3 to 4 hours is an emergency that needs hospital treatment to avoid permanent damage to the penis. If you have worsening or persistent pain in the area after the injection, contact your doctor quickly (Source: NHS).

Penis Botox Before and After: What to Expect

Do not expect a visible size change in penis Botox before and after photos: the measured changes in studies are erection hardness scores, penile blood flow on ultrasound and, for retraction, flaccid length. Any improvement usually appears within weeks, peaks around three months and then fades, so the result is temporary (Sources: Andrology RCT, 2021, Journal of Sexual Medicine, 2009).

Who May Consider Penis Botox, and Who Should Not?

Penis Botox is best discussed only after the standard treatments have been tried. It has been studied in adult men with vasculogenic ED that did not respond to PDE5 tablets or standard injections, and in men whose penis looks short only when flaccid because it retracts, despite a normal erect length (Sources: Andrology RCT, 2021, Journal of Sexual Medicine, 2009).

It is not a solution for men who want a longer or thicker erect penis. Anyone with a muscle or nerve disease, an allergy to botulinum toxin products, bleeding problems or an infection at the injection site, and anyone who has had a botulinum toxin injection in the past four months, should tell the doctor before treatment (Source: MedlinePlus).

For a long-lasting answer to severe ED, a penile implant is the guideline-recommended option when other treatments fail; read about the penile implant in Turkey (Source: EAU Guidelines).

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